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Endocrine Abstracts

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ea0037oc4.1 | Diabetes | ECE2015

Novel glucagon receptor antagonist peptides improve glycaemic control and partially protect against streptozotocin induced diabetes in mice

O'Harte Finbarr , McShane Laura , Irwin Nigel

Glucagon receptor KO mice are resistant to the clinical manifestations of diabetes induced by streptozotocin (STZ) and retain normal glycaemic control and glucose tolerance. In the present study the effects of chronic (18 days) once daily i.p. administration of two different glucagon receptor antagonists (GRA); desHis1Pro4Glu9-glucagon (GRA-1) and its related acylated peptide desHis1Pro4Glu9(Lys12PAL)...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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